NOAA’s daily Optimum Interpolation Sea Surface Temperature (dOISST, also known as Reynolds’ SST or OISST) is a global SST analysis product. An SST analysis is a spatially gridded product created by interpolating and extrapolating data, resulting in a smoothed spatially-complete field. dOISST provides global fields that are based on a combination of ocean temperature observations from satellite and in situ platforms (i.e., ships, buoys, and Argo floats). The input data are irregularly distributed in space and time and must be first placed on a regular 0.25° grid. The OISSTv2.1 methodology also includes bias adjustment steps of (a) ship SST bias correction according to buoy and Argo SST and (b) satellite SST bias correction according to in situ SST. Optimum interpolation (OI), a spatial interpolation method, is applied to the bias-corrected observed data to estimate values in regions without observations. In general, SST analyses including OISST are used in a range of applications including weather forecasting, climate studies, modeling, ENSO monitoring and prediction, marine ecosystem monitoring, commercial and recreational fisheries, marine heatwaves, and as a reference field for other satellite algorithms.